Understanding how the chordate body plan originated and evolved is still controversial. The discovery by Spemann and Mangold in 1924 of the vertebrate organizer and its inductive properties in patterning the AP and DV axis was followed by a long gap until the 1960s when scientists started characterizing the molecular events responsible for such inductions. However, the evolutionary origin of the organizer itself remained obscure until very recently; did it appear together with the origin and radiation of vertebrates, or was (...) it a chordate affair? A recent study by Yu and collaborators,1 which analyses the expression of several organizer‐specific genes in amphioxus together with recent phylogenetic data that reversed the position of invertebrate extant chordates (e.g. urochordates and cephalochordates), indicates that the organizer probably appeared in early chordates. It likely had separate signalling centres generating BMP and Wnt signalling gradients along the DV and AP axis. The organizer was then lost in the urochordate lineage, most probably as an adaptation to a rapid and determinate development. BioEssays 29:619–624, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

This paper argues that professionals who make boundary-related decisions should be guided by relationship-based practice. In our roles as service users and professionals, drawing from our lived experiences of professional relationships, we argue we need to move away from distance-based practice. This includes understanding the boundary stories and narratives that exist for all of us – including the people we support, other professionals, as well as the organisations and systems within which we work. When we are dealing with professional boundary (...) issues, we should centre relationship-building skills that are central to many other aspects of our work. Skills that foster relationships at all levels – between professionals, service users, and services – need to be revalued. Our final recommendation is to create, develop, and foster safer spaces within and outside of organisations, as well as inter-professionally, for the discussion and exploration of boundary-related issues and practice. We are interested in hearing from those with experiences of being marginalised by boundaries so that they can inform a reshaping of our collective ideas around boundary related practices. To foster relationship-based practices in organisations, we have outlined several recommendations here; however, we recognize that these do not go far enough, and that collective action is needed to inform systemic change. (shrink)

For over 20 years, the Schmid Training Course (STC) has offered unique opportunities for marine biology students from European universities to learn about marine model organisms. While the topics of the course have continuously changed over the years with the advent of new research techniques and discoveries, the pedagogical approach has remained largely the same – a combination of lectures, lab practicals, and field excursions. Several life science researchers, who have taught in the STC for many years, sought to bring (...) the course's pedagogical approach into the 21st century, and with the support of Erasmus+ Programme of the European Community funding, the Digital Marine project was developed. Digital Marine began in 2018 as an international partnership between the six research centers from which the STC instructors hail, and its main objective was to introduce a flipped, blended approach to learning and teaching with respect to established and emerging marine biological model systems. The Digital Marine platform, which covers 12 marine model organisms, is now publicly available. (shrink)

Besides indicating the fundamental themes of the various contributions that come together in this monographic section, the purpose of this introduction is to recall the main features of the Hobbesian concept of power, starting from the belief that Hobbes’ philosophy is above all a phi-losophy of power. Based on a radical materialistic ontology, the Hobbesian semantics of power takes on different variations in the particular discursive fields it crosses, which in turn significantly influence its movement. The double dependence on the (...) authority of the sovereign and on the opinion of the people ultimately highlights the aporetic character of the Hobbesian notion of power. (shrink)

In this paper, we examine how organizations’ impression management evolves in response to rising stakeholder pressures regarding organizations’ corporate responsibility initiatives. We conducted a comparative case study analysis over a period of 13 years for two organizations—Exxon and BP—that took extreme initial stances on climate change. We found that as stakeholder pressures rose, their IM tactics unfolded in four phases: advocating the initial stance, sensegiving to clarify the initial stance, image repairing, and adjusting the stance. Taken together, our analysis of (...) IM over these four phases provides three key insights about the evolution of IM in the face of rising pressures. First, when faced with stakeholder pressures, it seems that organizations do not immediately resort to conforming but tend to give in gradually when pressures increase and start to come from relatively powerful stakeholders. Second, evolution of IM seems to be characterized by path dependence, i.e., even as organizations’ positions evolve, they continue to show their conviction in their initial positions and try to convey that their subsequent positions flow logically from the previous ones. Finally, IM involves navigation between symbolism and substance, and companies tend to strive toward harmonizing their symbolic and substantive actions as stakeholder pressure increases. (shrink)

Compared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error (...) computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor. Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. (shrink)

The ageing society poses significant challenges to Europe’s economy and society. In coming to grips with these issues, we must be aware of their ethical dimensions. Values are the heart of the European Union, as Article 1a of the Lisbon Treaty makes clear: “The Union is founded on the values of respect for human dignity…”. The notion of Europe as a community of values has various important implications, including the development of inclusion policies. A special case of exclusion concerns the (...) gap between those people with effective access to digital and information technology and those without access to it, the “digital divide”, which in Europe is chiefly age-related. Policies to overcome the digital divide and, more generally speaking, e-inclusion policies addressing the ageing population raise some ethical problems. Among younger senior citizens, say those between 65 and 80 years old, the main issues are likely to be universal access to ICT and e-participation. Among the older senior citizens, say those more than 80 years old, the main issues are mental and physical deterioration and assistive technology. An approach geared towards the protection of human rights could match the different needs of senior citizens and provide concrete guidance to evaluate information technologies for them. (shrink)

Il saggio ha come oggetto di riflessione quella struttura portante della vita, dell'esperienza umana che č la speranza. Come l'angoscia e l'attesa, essa vive nel futuro e qui viene esplorata nel campo delle relazioni umane, d'aiuto, di cura, in psichiatria, con connotazioni tipiche che si aggiungono a quelle filosofiche e teologiche sull'argomento. Quando la speranza rinasce dalle secche del mal di vivere, quando il medico stesso si č confrontato con le debolezze proprie e attraverso l'empatia si č messo anche in (...) ascolto del silenzio del paziente, del dialogare in silenzio, allora la speranza č come un ponte che ci fa uscire dalla nostra solitudine e diventa speranza creatrice. (shrink)

The ageing society poses significant challenges to Europe’s economy and society. In coming to grips with these issues, we must be aware of their ethical dimensions. Values are the heart of the European Union, as Article 1a of the Lisbon Treaty makes clear: “The Union is founded on the values of respect for human dignity…”. The notion of Europe as a community of values has various important implications, including the development of inclusion policies. A special case of exclusion concerns the (...) gap between those people with effective access to digital and information technology and those without access to it, the “digital divide”, which in Europe is chiefly age-related. Policies to overcome the digital divide and, more generally speaking, e-inclusion policies addressing the ageing population raise some ethical problems. Among younger senior citizens, say those between 65 and 80 years old, the main issues are likely to be universal access to ICT and e-participation. Among the older senior citizens, say those more than 80 years old, the main issues are mental and physical deterioration and assistive technology. An approach geared towards the protection of human rights could match the different needs of senior citizens and provide concrete guidance to evaluate information technologies for them. (shrink)

Il cinquantennio a cavallo tra '200 e '300 rappresenta il periodo più stimolante e creativo per la riflessione sul rapporto tra necessità e contingenza e tra intelletto e volontà. L'A. analizza la difesa compiuta da Giovanni della tesi scotista sulla contingenza della fruizione beatifica, ossia sulla possibilità che il beato, in presenza della stessa essenza divina, possa mantenere la propria capacità di scelta, al punto tale da poter essere in grado di non abbandonarsi all'amore verso di Dio. Prima di analizzare (...) in modo più dettagliato il pensiero del Reading, l'A. passa in rassegna le posizioni di Duns Scoto, Roberto Cowton, Riccardo di Conington, Guglielmo d'Occam, Pietro Aureolo che, in terra francese, diversamente da Francesco di Meyronnes e Giovanni di Bassoles, non aderì alla tesi scotista della contingenza della fruizione. All'interno di questo programma teorico Reading si oppone innanzitutto ai teologi inglesi che, legati a posizioni tradizionali, sostenevano la necessità in via come in patria della fruizione del sommo bene colto come concetto o contemplato come essenza. In appendice vien pubblicata l'ed. della sesta quaestio della prima distinctio del Commento alle Sentenze di Giovanni Reading basata sul ms. Firenze, B.N.C., Conv. Soppr. D IV 95. (shrink)

"Siamo come lucciole che hanno disimparato a illuminare e che prima si sono messe a girare attorno alla lanterna magica dell'ideale ascetico e ora attorno alle insegne pubblicitarie al neon. Lucciole che hanno scordato d’avere una potenzialità di orientatività preziosa nel proprio sistema affettivo" (G. Cusinato, La totalità incompiuta, Milano 2008, 314). Che cos'è una persona? Come si costituisce concretamente l'identità personale? Che rapporto c'è fra identità personale e identità psichica? C'è coincidenza fra persona e homo sapiens? La persona è (...) ancora oggi, nonostante tutto, al centro del dibattito filosofico, sociologico, giuridico e bioetico, eppure la sua dimensione sembra sfuggire continuamente alle reti concettuali e alle categorie epistemologiche della scienza. In questo lavoro si propone una fenomenologia della persona a partire dal confronto con la teoria dei sistemi autopoietici di Maturana e Varela e dei sistemi sociali di Luhmann, mettendo in luce che la persona non può essere considerata un sistema autopoietico. La persona si delinea piuttosto come un sistema excentrico che si costituisce mediante l'esecuzione dell'atto. Questa prospettiva viene esplorata attraverso un dialogo serrato con l'antropologia filosofica tedesca, la stessa che all'inizio del Novecento mette in luce che l'uomo non ha un'essenza precostituita e proprio per questo necessita di un processo di Bildung. L'antropologia filosofica di Scheler e Plessner nasce nella Germania degli anni Venti in un periodo ancora fluido in cui l'eclissi delle tradizionali concezioni dell'uomo non aveva ancora lasciato il posto alla cristallizzazione totalitaria dell'uomo di massa che si sarebbe imposta negli anni Trenta. (shrink)

Con "Fede e critica", saggio inedito del 1955-1956, Guido Morselli volle innanzitutto spiegare a se stesso, ragionando con quella lucidità ben nota ai lettori dei suoi romanzi, un passaggio decisivo della sua vita, in cui si sentì ricondotto, dalla sua posizione di «uomo qualsiasi... senza alcuna particolarità pia o edificante» a quella di uomo religioso. Piuttosto che darci ancora una volta «il racconto, drammatico o più spesso patetico, di una conversione», illuminato perciò da un punto d’arrivo, Morselli ha voluto (...) offrirci la sua vicenda «nella successione degli aspetti che le cose hanno mostrato via via che si presentavano». Perciò, al sorprendente manifestarsi di una ‘fede’ si accompagna qui a ogni passo la lama affilata della ‘critica’, una dura critica che vuole continuamente mettere «con le spalle al muro» le giustificazioni teologiche – innanzitutto per quanto riguarda il rapporto fra Dio e il male – e insieme mettere alla prova quell’ignoto personaggio che, all’interno del soggetto, dichiara appunto di credere. Nulla di apologetico, conciliativo o acquietante si troverà dunque in questo libro, che rivela l’altra parte, saggistica e speculativa, del narratore Morselli, ma una mobilissima e pulsante «fisiologia della vita religiosa», in forma di resoconto scritto da uno spirito disincantato sulla scoperta del mistero. Tutti i più grandi temi ed enigmi della religione cristiana vengono toccati in questo percorso: dalla carità al "Libro di Giobbe", dall’esistenza del male alla preghiera, dalla Trinità al peccato originale. E su tutti questi punti il ‘dilettante’ Morselli parla con rigoroso acume ‘critico’, ma soprattutto con una straordinaria capacità di rendere concreto ciò che ciascuno di quei grandi temi veniva a rappresentare, come d’improvviso, nella sua esperienza personale. Così egli ci offre un saggio che è anche un prezioso frammento di autobiografia e vuole consapevolmente «confermare la sentenza di Nietzsche: essere la nostra filosofia nient’altro che il compendio delle nostre memorie». E anche delle memorie future: sicché non saremo meravigliati quando, alla fine di un capitolo, troveremo alcune parole che poi sarebbero comparse, in forma quasi uguale, nel romanzo Roma senza papa: «E in ogni caso, non dimentichiamolo: Dio non è teologo. Dio non è prete». (shrink)

Participatory and collaborative approaches in sustainability science and public health research contribute to co-producing evidence that can support interventions by involving diverse societal actors that range from individual citizens to entire communities. However, existing philosophical accounts of evidence are not adequate to deal with the kind of evidence generated and used in such approaches. In this paper, we present an account of evidence as clues for action through participatory and collaborative research inspired by philosopher Susan Haack’s theory of evidence. Differently (...) from most accounts of evidence for use in policies and interventions, our account combines action-oriented (the how) and actors-oriented (the who) considerations. We build on Haack’s theory and on the analysis of examples of participatory and collaborative research in sustainability science and public health research to flesh out six procedural criteria for the generation and mobilization of evidence in and from participatory research. Action-oriented criteria invite to look at evidence from a (a) foundherentist, (b) gradational and (c) quasi-holistic perspective. Actors-oriented criteria point out that evidence generation and utilization are (d) social, (e) personal, and (f) embedded. We suggest that these criteria may reinforce participatory and collaborative approaches to evidence co-production when addressing complex problems in sustainability science and public health allowing for the generation of a kind of practical objectivity. (shrink)

L’Italia rappresenta un luogo del tutto peculiare per gli sviluppi del pragmatismo, fin dai suoi albori. A partire dalla fondazione del Leonardo nel 1903, Giovanni Papini, Giuseppe Prezzolini, Giovanni Vailati, Mario Calderoni (e molti altri) contribuirono a riprendere e a diffondere in Europa le principali istanze dei pragmatisti d’oltreoceano. Come è noto, questi filosofi non si limitarono ad essere vivaci interpreti del pensiero di Charles Sanders Peirce e William James, ma elaborarono anc...

In un verso di Ariosto, la sorte di Giordano Bruno. SPECIALE V CENTENARIO ORLANDO FURIOSO (1516–2016).

La plupart des commentateurs de Parménide ont presque exclusivement fixé leur attention sur la doctrine de l’être. Mais le poème était beaucoup plus long. Le fait que seule une petite fraction de la deuxième partie nous soit parvenue ne veut pas dire que cette partie ne soit pas essentielle pour la compréhension de la première. C’est donc à l’étude de cette deuxième partie que Rossetti a consacré son livre. Il avoue d’emblée être tombé sur un Parménide bien différent de celui (...) de la tradition... (shrink)

Among the studies on the history of philosophy recently published in Italy, one that may be of some interest to the English reader is by D R . Abbagnano , a young pupil of Aliotta , and is devoted to the new English idealism. 1 Truthfully speaking, the term ‘ new ’ is inappropriate, or partly so, because Abbagnano dedicates the greater part of his study to what we might call the ‘ old ’ idealism in England, represented by Stirling, (...) the two Cairds, Wallace, Green, and Bradley. However, he does also pass in review the more recent doctrines, particularly those of J. H. Muirhead, G. H. Howison, D. G. Richtie, J. E. Creighton, J. B. Baillie, J. S. Mackenzie, H. Jones, W. E. Hocking, A. S. Pringle Pattison, and G. P. Adams. Abbagnano regards as a distinctive trait of English idealism inspired by Hegel as opposed to Hegel himself, this, that “for Hegel the absolute is essentially process, change and becoming; it is thought which differentiates itself and becomes articulate in a life of its own, in the threefold rhythm of thesis, antithesis, and synthesis, in which each moment passes into the next. For Green, Bradley, and Royce, the absolute is on the other hand immutability, completeness, static perfection, in which each process and becoming is overcome and resolved.” At any rate, Abbagnano is equally unsympathetic towards Hegel and towards his followers, against whom he opposes, not without scholastic ingenuity, his own irrationalistic views, set out in another book whose contents are sufficiently expressed in the title. 1. (shrink)

Among the studies on the history of philosophy recently published in Italy, one that may be of some interest to the English reader is by D R . Abbagnano , a young pupil of Aliotta , and is devoted to the new English idealism. 1 Truthfully speaking, the term ‘ new ’ is inappropriate, or partly so, because Abbagnano dedicates the greater part of his study to what we might call the ‘ old ’ idealism in England, represented by Stirling, (...) the two Cairds, Wallace, Green, and Bradley. However, he does also pass in review the more recent doctrines, particularly those of J. H. Muirhead, G. H. Howison, D. G. Richtie, J. E. Creighton, J. B. Baillie, J. S. Mackenzie, H. Jones, W. E. Hocking, A. S. Pringle Pattison, and G. P. Adams. Abbagnano regards as a distinctive trait of English idealism inspired by Hegel as opposed to Hegel himself, this, that “for Hegel the absolute is essentially process, change and becoming; it is thought which differentiates itself and becomes articulate in a life of its own, in the threefold rhythm of thesis, antithesis, and synthesis, in which each moment passes into the next. For Green, Bradley, and Royce, the absolute is on the other hand immutability, completeness, static perfection, in which each process and becoming is overcome and resolved.” At any rate, Abbagnano is equally unsympathetic towards Hegel and towards his followers, against whom he opposes, not without scholastic ingenuity, his own irrationalistic views, set out in another book whose contents are sufficiently expressed in the title. 1. (shrink)

This new, second edition of the popular college textbook offers the beginning philosophy student a comprehensive introduction to several aspects of one of the most influential schools of thought in the twentieth century. Professor Klemke begins by pointing out the distinctions among the various types of analytic and linguistic philosophies, while emphasising that they all arose as a response to the formerly predominant school of absolute idealism. After a prologue section containing a representative exposition of idealism by Josiah Royce, the (...) following sections show the radically new philosophical approach of the analytic school in its various guises: realism and common sense (G. E. Moore); logical atomism (Bertrand Russell); logical positivism (A. J. Ayer); conceptual analysis (Gilbert Ryle, G. E. Moore, John Wisdom); logico-metaphysical analysis (Gustav Bergman, W. V. Quine); linguistic analysis (J. L. Austin, P. F. Strawson, J. R. Searle); and the recent development of new realism (Saul Kripke, Hilary Putnam, Tyler Burge, Richard N. Boyd). (shrink)